MiLO
MiLO (RUO*) is an automated electrodynamic cell lysis device. It uses precisely controlled electric fields to selectively lyse mammalian cells in complex biological samples – without chemicals, without bias, and without touching the cells you want to keep.
Finally solving the crap in crap out problem.
The result is a clean, controlled lysis event in milliseconds: human cells are disrupted, microbial cells remain intact, viable und unchanged, and your downstream workflow receives a sample that is simpler, purer, and ready for analysis.
*Research Use Only
Why should you care?
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This matters if you want to be able to detect microbes faster AND get the full picture.
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No matter if you want to detect your growing microbes faster, or get their DNA sequenced faster.
- No matter from which complex biological samples (including blood and blood derived sample matrixes, respiratory samples like sputum and cell cultures.)
Use MiLO for mNGS sample preparation
MiLO removes the sample background, the noise hiding and delaying your signal. This matters for metagenomic sequencing because host DNA is the dominant barrier to reliable microbe detection. In an unprocessed sample, 95–99% of sequencing reads map to the human genome. MiLO removes that background electrodynamically – no reagents, no chemical interference, no pathogen loss – so your sequencing capacity goes where it should: the microbes.
USPs
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Chemical-free lysis
MiLO uses a pure electromagnetic mode of action – no detergents, no chaotropic agents. Only electric fields, eliminating chemical bias and interference with downstream molecular workflows. -
Binary cell selectivity
Mammalian and microbial cells respond differently to electric fields. MiLO exploits this difference precisely: human cells are lysed, microbial cells stay intact and viable. -
Effective in milliseconds
The lysis event is physical, it happens in milliseconds. One button, one cartridge, fully automated. -
Multiple applications, one device
MiLO’s electrodynamic mechanism is agnostic to sample type, and microbes and adaptable across downstream workflows.
Applications
- Leading host DNA depletion for metagenomics NGS
Capture all microbial DNA
Reproducible
Reliable
- Improved recovery of hard-to-isolate species
Recover all viable microbes
Delete all the background
- 70% Faster microbial growth detection
Increased performance and bacterial coverage for rapid AST
Recover all viable microbes
Delete all the background
- On-plate solution to skip blood culture from whole blood
Directly from whole blood
Microbe recovery on filter without loss
Wash out inhibitors